Selected Publications


Asparagine availability governs metastasis in a model of breast cancer.

Knott SRV*, Wagenblast E*, Kim SY, Soto M, Khan S, Gable AL, Maceli AR, Dickopf S, Erard N, Harrell C, Perou CM, Wilkinson JE, Hannon GJ. (*first author)
Nature. 2018 Feb 7. doi: 10.1038/nature25465

Related news articles:
The Times: Laying off asparagus may help beat cancer
USA Today: Could cutting asparagus from your diet stop the spread of cancer?
The Guardian Spread of breast cancer linked to compound in asparagus and other foods
BBC News: Food may influence cancer spread
Huffington Post: Should I Stop Eating Asparagus To Halt Cancer's Spread?
Boston Globe: New study suggests diet could affect deadly spread of breast cancer
The Independent: Potential key to halting breast cancer's spread discovered by scientists

feb. 2018; 

Jul. 2017;
Mol Cell

A CRISPR Resource for Individual, Combinatorial, or Multiplexed Gene Knockout.

Erard N, Knott SRV, Hannon GJ.
Mol Cell. 2017 Jul 20;67(2):348-354.e3. doi: 10.1016/j.molcel.2017.06.030.

Selected into the annual "Best of Molecular Cell" collection.

Related news article:
Genomeweb: TransOmic, CSHL-Led Team Partner to Push AI-Driven CRISPR/Cas9 Design Tool to Market

Apr. 2015;

A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis.

Wagenblast E, Soto M, Gutiérrez-Ángel S, Hartl CA, Gable AL, Maceli AR, Erard N, Williams AM, Kim SY, Dickopf S, Harrell JC, Smith AD, Perou CM, Wilkinson JE, Hannon GJ, Knott SR.
Nature. 2015 Apr 16;520(7547):358-62. doi: 10.1038/nature14403. Epub 2015 Apr 8.
PMID: 25855289

Related news articles:
Nature | News & Views: Cancer: An extravascular route for tumour cells
Science Mag: Tumors have found a bloody new way to grow and spread
F1000: Article Recommendation

Dec. 2014;
Mol Cell

A computational algorithm to predict shRNA potency.

Knott SR, Maceli AR, Erard N, Chang K, Marran K, Zhou X, Gordon A, El Demerdash O, Wagenblast E, Kim S, Fellmann C, Hannon GJ.
Mol Cell. 2014 Dec 18;56(6):796-807. doi: 10.1016/j.molcel.2014.10.025. Epub 2014 Nov 26.
PMID: 25435137

Related news article:
Science Daily: Making shRNA gene knockdown more effective

Jan. 2012;

Forkhead transcription factors establish origin timing and long-range clustering in S. cerevisiae.

Knott SR, Peace JM, Ostrow AZ, Gan Y, Rex AE, Viggiani CJ, Tavaré S, Aparicio OM.
Cell. 2012 Jan 20;148(1-2):99-111. doi: 10.1016/j.cell.2011.12.012.
PMID: 22265405